Seven proteins namely TFF3, LCN2, CEACAM5, TFF1, SELE, RETN, and AHCY proteins of both phases were found to be upregulated in colorectal cancer in human protein atlas database, also were significant in our UK Biobank dataset and had an essential function in CRC (Supplementary Table S8). This evidence concerns the gene TFF3 and colorectal carcinoma.