LCN2 and colorectal cancer: TFF3 and LCN2 were found to be the top most significant proteins in the UK Biobank.TFF3 and LCN2 were found to be highly expressed in other cancers like Myeloma, and lung cancer in the human protein atlas database.TFF3 was the most significant protein found in our study and played an important role in the proliferation, migration, and invasiveness of HT29 cells in colorectal cancer (67).TFF3 has a physical association with PCBD1, UBQLN2, and SGTA which were considered to be transcription factors and other protein classes in the human protein atlas database (Supplementary Figure S9A).