who generated a mouse strain that transgenically expresses the human cytokines: stem cell factor (SCF), GM-CSF, and IL-3 (SGM3) in a NOD/SCID background, termed NOD/LtSz-scid IL2RG-SGM3 (NSGS), which resulted in improved engraftment of AML cells from patients with various aberrations even compared to the original NSG model (5). Here, KITLG is linked to acute myeloid leukemia.