Compared to the patient sample, the cytological (Figure 2A) and flow cytometry profiles (Figure 2C; Supplementary Figure 3B) were preserved in the PDX-AML-2 model, and pathogenic mutations of ASXL1, CBL, TET2 and ZRSR2 persisted alongside deletion of a chromosome 7. This evidence concerns the gene CBL and acute myeloid leukemia.