BRAF and Fever: In contrast, in the published results of the randomized Phase II study (NCT02684058) of first-line dab + tram vs C+V in BRAF V600–mutant pLGG, the most common toxicity in the 73 patients on the dab + tram arm was pyrexia (68%), followed by headache (47%), and vomiting (34%) (4, 18).