Research has demonstrated that selenoproteins, such as selenoprotein P (SelP), glutathione peroxidase (GPx), thioredoxin reductase (TXNRD), and selenoprotein F (SEP15, SelF), exert regulatory effects on tumorigenesis and tumor progression through modulation of cancer-associated signaling pathways (170). The gene discussed is SELENOF; the disease is cancer.