In a hydrocephalus rat model after IVH, the phosphorylation of NKCC1 was increased via the activation of NLRP3 inflammasome components, which indicated the involvement of the NLRP3/p-NKCC1 pathway and Na+ and K+ flux in the PPH (Zhang et al., 2022). Here, SLC12A2 is linked to Hydrocephalus.