CD274 and Marinesco-Sjogren syndrome: Reports suggest that combining multi-pathway approaches with PD-1/PD-L1 inhibitors improves the effectiveness of anti-PD-1/PD-L1 therapy in MSS CRC by increasing CD8+ T cell counts, upregulating PD-L1 expression, and enhancing the tumor microenvironment (Cai et al., 2024).