We observed G2M and S phase cells at velocity start point in ACME HS and enzymatic specific clusters as well as differential expression of cell cycle controlling and neuroendocrine tumor proliferation genes–MAD2L1, CENPW, PCLAF, PTTG1, UBE2C, CDKN3 for adrenocortical cells and CLU, VGF, CD24, PEG10, SCOC, CKB for chromaffin cells in all samples. This evidence concerns the gene MAD2L1 and neuroendocrine neoplasm.