AP1S1 encoded the shell of a lattice protein, and its down-regulation leads to the degradation of EGFR-containing lysosomes in NSCLC, affecting the intracellular transport of EGFR, which in turn decreases cell-surface levels of EGFR and affects the therapeutic efficacy of EGFR-TKI (35). The gene discussed is AP1S1; the disease is non-small cell lung carcinoma.