INS and Other metabolic disease: One important risk factor for metabolic diseases is obesity.Adipocytes in obese people become hypertrophic and dysfunctional, which changes the production of adipokines like adiponectin and leptin.Systemic insulin resistance is exacerbated by adipose tissue malfunction, which fosters ectopic lipid buildup and persistent low-grade inflammation (18).Adipose tissue free fatty acids (FFAs) are released more often in insulin-resistant individuals, and their livers absorb more of them.