LCN2 and Ureteral obstruction: Treatment with sacubitril/valsartan or valsartan diminished the level of kidney injury molecule (KIM)-1, neutrophil gelatinase associated lipocalin (NGAL) in various animal models including dogs and mice with CRS, db/db and KKAy mice, ZO rats and unilateral ureteral obstruction (UUO) rats (39, 42, 45–47).