For example, the PET radiotracer [11C] CPPC targeting the CSF1R marker in microglia has demonstrated increased uptake in murine and non-primate models of neuroinflammation (96), murine models of Alzheimer’s disease (AD) (97), AD postmortem brain tissues (98), epilepsy seizure imaging (99), and PET imaging of microglial activation in patients with multiple sclerosis or cerebellar ataxia in HIV infection (100, 101). This evidence concerns the gene CSF1R and Alzheimer disease.