C-type lectin domain family 4, member E (Clec4e, also known as Mincle), is markedly expressed on the surface of M1 macrophages, detecting pathogens and endogenous ligands, thereby initiating innate immunity in the realms of host defense, immune disorders, infectious diseases, inflammation, and even tumors (125). The gene discussed is CLEC4E; the disease is immune system disorder.