Although there are many indicators used to predict the prognosis of patients with sepsis, including lactate (6, 7), neuron-specific enolase (8, 9), end-tidal carbon dioxide (10), fibroblast growth factor 23 (11), and growth differentiation factor-15 (12, 13), there are still few indicators that can evaluate PH patients with sepsis. Here, ENO2 is linked to Sepsis.