CEACAM5 and neoplasm: Factors suggesting a higher risk of LRRC include postoperative CEA levels, surgical aspects (higher residual tumor [R] classification, with R1/2 being worse than R0, intraoperative perforation, abdominoperineal resection), and tumor characteristics such as advanced T-stage, low rectal tumors, positive circumferential resection margin (CRM), lymphovascular invasion, nodal metastasis, extramural venous invasion and poor tumor differentiation [3,5,6].