FMR1 and premature ovarian failure 1: We do not expect to find premutation disorders in these families, including Fragile X-associated Tremor Ataxia Syndrome (FXTAS), Fragile X-associated Neuropsychiatric Disorders (FXAND), and Fragile X-associated Primary Ovarian Insufficiency (FXPOI), because they do not have elevated FMR1 mRNA leading to RNA toxicity.