MKRN3 and central precocious puberty: Notably, 2 distinct studies evaluated the functional impact of 4 missense MKRN3 mutations previously identified in patients with CPP; 2 (p.Cys340Gly and p.Arg365Ser) were located on the RING finger domain and 2 (p.Phe417Ile and p.His420Gln) were located on the C-terminal zinc-finger domain [52, 56].