Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary CSVD, characterized as a rare genetic disorder in the NOTCH3 gene with non-atherosclerotic and non-amyloid diffuse angiopathy, which mainly leads to brain parenchyma lesions (Yuan et al., 2024). Here, NOTCH3 is linked to cerebral arteriopathy with subcortical infarcts and leukoencephalopathy.