PLA2G7 and early-onset autosomal dominant Alzheimer disease: In addition, Lp-PLA2 also plays an important role in the prediction of the development of diseases such as atherosclerosis, Alzheimer’s disease, diabetic retinopathy, tumors, etc., especially a promising marker for intracranial atherosclerosis (Huang et al., 2019; Wang Y. et al., 2022).