Biochemical indicators showed that pro-inflammatory factors IL-6 (p < 0.01), IL-1β (p < 0.001), and TNF-α (p < 0.01), decreased, while the anti-inflammatory factor IL-10 increased (p < 0.05) in the brains of zebrafish treated with HRW in Figures 6D–G, indicating that HRW improved the inflammatory microenvironment in the brains under AD conditions. Here, TNF is linked to Alzheimer disease.