CALB1 and early-onset autosomal dominant Alzheimer disease: More directly relevant to this discussion, post-mortem brain tissue donated by COVID-19 patients revealed abnormalities in shared pathways associated with Alzheimer's disease, including those involved innate immunity, tau hyperphosphorylation, as well as a site-specific calbindin hypoactivity in the hippocampus (Reiken et al., 2022).