HCRT and ischemic stroke: Wu et al. (2022) have shown that Hcrt-1 was lowly expressed in the brains of rats with ischemic stroke. Upregulating Hcrt-1 could improve sleep architecture of post-stroke rats, such as total sleep time, non-rapid eye movement frequency, and frequency of rapid eye movement (Wu et al., 2022). Given that hypertension is a risk factor for stroke, the promotion of Hcrt-1 secretion might be involved in the onset of sleep problems by regulating blood pressure (Wang et al., 2011; Gorgui et al., 2014).