High uric acid levels may contribute to lipid metabolism disorders through various mechanisms, including inhibition of Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) signaling and activation of Sterol Regulatory Element Binding Protein 1c (SREBP-1c), which promotes fat synthesis (59, 60). This evidence concerns the gene SREBF1 and Disorder of lipid metabolism.