In particular, genes involved in the cell cycle and DNA repair were identified as essential, suggesting compensatory mechanisms when these pathways are disrupted.70 However, our results suggested that the deletion of mutant KRAS G12S alleles by C14-PEI micelleplexes can effectively inhibit tumour cell proliferation and migration, and promote the apoptosis of tumour cells after treatment, likely through downregulation of the AKT and ERK signalling pathways. Here, AKT1 is linked to neoplasm.