Among 27,643 patients with type 2 DM, 32.5% (8990) of them were aged ≥ 65 years 57.8% (15,994) were male, 51.8% (14,308) had malignant tumors, 5.5% (1529) had a history of ischemic stroke, 51.4% (14,214) were on insulin medication, and 8.6% (2382) underwent neurosurgery. This evidence concerns the gene INS and ischemic stroke.