SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Thus, given the high prevalence of total LoF variants and phenotypic variability seen in this study, the clinician should consider use of the diagnosis of Dravet syndrome for patients with complete LOF SCN1A variants presenting with febrile seizures before one year of age, even if they have not yet developed drug‐resistant epilepsy or intellectual disability.7, 36