Pathogenic SCN1A variants are among the most common identified etiology for monogenic epilepsy,4, 5, 12 and are associated with a variety of epilepsy phenotypes, ranging from mild (genetic epilepsy with febrile seizures plus [GEFS+]) to severe (Dravet syndrome).13, 14. This evidence concerns the gene SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.