TREM2 and hepatocellular carcinoma: However, when 2-deoxyglucose (2-DG) was used to inhibit glycolytic function [26], the differences in the proliferation of Hepa 1–6 cells between the WT and Trem2−/− groups were eliminated (Fig. 5B), indicating that the TREM2+macrophage-promoted malignant phenotypes of HCC are related to glycolysis.