These findings align with a recent study showing that TREM2+ macrophages secrete lower levels of CXCL9 but increased levels of galectin-1, which mediates PD-L1 overexpression in vascular endothelial cells and impedes CD8+ T cell recruitment after transarterial chemoembolization in HCC [32]. The gene discussed is CXCL9; the disease is hepatocellular carcinoma.