MAPT and Alzheimer disease: Regarding the association of liver and renal function with AD, the liver and kidney physiologically remove Aβ from the blood and regulate Aβ levels in the brain; an age-related decline in hepatic Aβ clearance may be involved in the development of AD [29–31]; and eGFR is positively correlated with Aβ42 and Aβ40 and negatively correlated with total-tau levels in CSF [32–34].