The activation of the RAS/RAF/MEK2/ERK/p90RSK/ERα phosphorylation cascade occurs through the involvement of BRD4 and RET, leading to tumor malignancy [72].Furthermore, there have been reports indicating that super enhancers play a role in promoting tumor growth in breast cancer through the regulation of long non-coding RNAs. This evidence concerns the gene RPS6KA1 and neoplasm.