SOD2 and type 2 diabetes mellitus: Our study shows that subjects with SNP (rs4880) in SOD2 gene (CT + TT) alleles have lower concentrations of s-folate and higher concentration of p-tHcy than subjects with (CC) alleles. These findings are novel and interesting considering previous reports where SOD2 (CT + TT) alleles have been associated with increased risk of CVD and type 2 diabetes, possibly due to decreased level or reduced activity of the SOD2 enzyme [48, 49].