BRCA2 and cancer: Furthermore, the IMPACT study, a screened population of men with LP/P BRCA1/2 variants with a PSA threshold of 3 ng/ml for biopsy showed similar cancer incidence rates of 14 and 19 per 1000 person-years compared to our 14 and 23 per 1000 person-years for men with LP/P variants in BRCA1 and BRCA2, respectively [21].