For every 2-fold increase in PSA, the risk of prostate cancer diagnosis increased 1.6 times (95CI: 1.1‒2.4, P = 0.01), and per 0.1 ng/ml/ml increase in PSA density, the risk of prostate cancer diagnosis increased 1.9 times (95CI: 0.97‒3.7, P = 0.06), and none of the other included variables were associated with increased prostate cancer risk (Table 2). This evidence concerns the gene KLK3 and prostate cancer.