ADCY10 and cervical squamous intraepithelial neoplasia: In both mouse and human 3T3 and HCT116 cells subjected to SAC inhibition, CDC20 depletion by siRNA or shRNA significantly alleviated Reversine-induced CIN, reducing the prevalence of severe mitotic aberrations in cells exposed to SAC inhibition (Figs. 4C–F and  EV5C,D).