Moreover, to further investigate whether the functions of Ephrin A1 in inducing EMT and metastasis of gastric cancer cells is EphA2 independent, we ectopically expressed Ephrin A1 in WT and EphA2-KO AGS cells and found that Ephrin A1 still significantly promoted EMT process in the absent of EphA2 (Fig. EV4D). The gene discussed is EPHA2; the disease is gastric cancer.