The current work supports previous findings by Wang et al. [5] showing that diet-induced obesity in mice versus chow-fed lean mice had increased GRK5 mRNA levels (~2 fold) in white, but not in brown adipose tissue (Fig. 1A, B).We also show here that Grk5 mRNA is abundant in the stromal vascular fraction, but not adipocyte fraction, of mouse white adipose tissue (Fig. 1C), supporting previous findings [10–12]. Here, GRK5 is linked to obesity due to melanocortin 4 receptor deficiency.