TNF and cancer: Furthermore, while MAPK, colorectal cancer, pathway in cancer, TNF signaling pathways were found to be prominent pathways in A549 (Fig. 3c), biosynthesis of aminoacid, carbon metabolism, glycolysis/gluconeogenesis pathways were found to be prominent pathways in HT29 with the synergetic effect of RJ and AVE applied together in both cell lines (Fig. 3f).