Increased cancer prognosis, metastatic process, and poor survival are observed in many cancer types, such as lung cancer, head and neck cancer, pancreatic cancer, and colon cancer with especially high expression of ENO1 protein, which shows intracellular and extracellular activation depending on cellular localization [43] and it is important for maintaining the Warburg effect for cancer cells [44]. Here, ENO1 is linked to colonic neoplasm.