A comparison of PCMbs–MR with anti-MET and anti-RON mAbs in receptor internalization using the PDAC cell line BxPC-3(MET3+/RON2+) and colorectal cancer cell line HCT116(MET2+/RON3+), both of which co-express high levels of MET and RON, is shown in Fig. 2g. This evidence concerns the gene NR3C2 and colorectal cancer.