When characteristics of the obesity group were compared according to TLR2 (Arg753Gln) genotypes, the BMI (p = 0.019), waist circumference (p = 0.031), hip circumference (p = 0.012), FBS (p = 0.023), cholesterol (p = 0.041), LDL-C (p = 0.043), leptin (p = 0.018), TNF-α (p = 0.025), and Wnt5a (p < 0.001) showed significantly lower values in the AA + GA model carriers compared to the homozygous GG genotype group. The gene discussed is TLR2; the disease is obesity due to melanocortin 4 receptor deficiency.