Therefore, the objective of this study was to (1) assess Wnt5a serum levels in association with the well-studied markers, TNF-α and leptin, to gain deeper insights into the mechanisms of obesity-related metaflammation and (2) investigate the link with TLR2 gene (Arg753Gln) SNP in a pilot sample of Egyptian females. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.