When the obesity group (n = 60) was classified according to the obesity class, the metaflammation markers under the study, leptin (p < 0.001), TNF-α (p = 0.007), and Wnt5a (p = 0.001), showed a significant increase with the higher obesity class. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.