NFKB1 and Keratoconjunctivitis sicca: Tβ4 can exert an immunomodulatory effect, which reduces the release of cytokines such as IL-1 receptor-associated kinase by regulating the NF-κB and Toll-like receptor pathways, thereby attenuating inflammatory injury48, it also has been reported to have a certain mitigating effect on inflammation in dry eyes as well26.