The level of GnIH expression has been linked to abnormal adolescent development and reproductive dysfunction.9 The loss of GnIH expression is believed to be a contributing factor to the onset of precocious puberty.34 It is also believed that GnIH antagonists could be developed into drugs for reproductive dysfunction, and whether fertility drugs developed for GnIH/Gpr147 increase the risk of osteoporosis needs to be studied and noted.33,51 In our study, we conducted long-term green light therapy on OVX mice, exposing them to up to 8 h per day. Here, NPFFR1 is linked to osteoporosis.