LIG4 and achondroplasia: Our results corroborate a report on another mouse model of pseudo-achondroplasia (the homozygous CompT585M knock-in model) characterized by disorganization of the growth plates, dysregulated apoptosis, and short limb dwarfism.77 Lastly, we observed impaired DNA repair in Fgfr3N534K/+ mice, as revealed by the downregulation of Alkbh2 (coding for a DNA repair enzyme that catalyzes the direct reversal of DNA methylation damage through oxidative demethylation).59 Overall, these results indicate that the Fgfr3N534K/+ mutation disturbs autophagy and apoptosis during bone callus formation.