CD4 and hepatocellular carcinoma: We then investigated the effects of Srsf1 on T cells under pathological stress by subjecting Srsf1fl/flCd4-Cre and Srsf1+/+Cd4-Cre mice to a CTNNB1N90; Trp53KO-induced autochthonous HCC model (Fig. 2b).