TCF7 and melanoma: A recent study demonstrated that by inhibiting ferroptosis, mTORC signaling serves as a crucial signaling hub to increase the lifespan of virus-specific memory CD4+T cells.37 Furthermore, a scRNA-seq study of CD8 T cells in human melanomas showed that patients receiving checkpoint inhibition had a better prognosis when CD8+T cells expressed more TCF7.35,37 Higher levels of Itgae, which codes for a transcription factor that stimulates the development of memory T cells, were expressed by SRSF1-KO T cells.