Therefore, we tested whether MALAT1 function contributes to cell survival in a model of neurodegeneration by evaluating the effects of alterations in MALAT1 and TDP-43 on cell viability and gene expression in SH-SY5Y neuroblastoma cells exposed to the neurotoxin 1-methyl-4-phenylpyridinium (MPP+). This evidence concerns the gene TARDBP and neuroblastoma.