We next repeated the TDP-43 IP-qPCR assays in the nuclear extracts of SH-SY5Y neuroblastoma cells treated with MPP+ in triplicate and found that TDP-43 binding to MALAT1 was significantly increased, while TDP-43 binding to the 3′ UTR of SLC1A5, CSNK1E, and HMGB2 mRNAs was significantly decreased (Fig. 6E). Here, TARDBP is linked to neuroblastoma.