Interestingly, several of the viruses that suppress GJIC have been reported to activate ERK1/2 early in infection, and this ERK1/2 activation is often associated with enhanced viral spread and replication (CMV [49-52], ZIKV [53], CSFV [47,54], MHV [55,56], Ad5 [57,58]). The gene discussed is MAPK3; the disease is infection.