Inhibitors targeting these different pathways (chloroquine diphosphate, wortmannin, and MG132 to inhibit autophagy, lysosomal degradation and the 26S proteasome, respectively) all noticeably but incompletely impaired PRV-induced Cx43 degradation (Fig 2G), suggesting that PRV-induced Cx43 degradation late in infection may occur via different degradation pathways. The gene discussed is GJA1; the disease is infection.