The SuStaIn model determined the spatiotemporal trajectories of tau protein for 4 AD subtypes: limbic-predominant (severe pathology in the limbic system and medial temporal lobe), medial temporal lobe (MTL)-sparing (severe pathology in the occipital and parietal lobes), posterior temporal (early pathological tau deposition in the occipital lobe), and lateral temporal (left hemisphere pathology more severe than right hemisphere) [55]; 88% of subjects could be categorized into one of these 4 subtypes. This evidence concerns the gene MAPT and Alzheimer disease.