HACD2 and pachyonychia congenita: To further elucidate the biological function of HACD2 in PC, we ectopically expressed and silenced HACD2 in the PANC‐1 and AsPC‐1 cell lines (Figure S2A–D, Supporting Information) and subsequently examined its effect on PC cell proliferation through Cell Counting Kit‐8 (CCK‐8) and plate cloning assays.