As a recessive gene involved in the pathogenesis of Parkinson's disease, PRKN can affect mitochondrial function, calcium homeostasis, synaptic function, and lysosomal/proteasome degradation.[39, 40, 41] In addition, PRKN plays an important role in tumorigenesis, and abnormal expression of PRKN can lead to uncontrolled growth and proliferation, inhibit cell death and induce angiogenesis. Here, PRKN is linked to Parkinson disease.