Gal-3 is associated with the progression and poor prognosis of thyroid tumors and is one of the driving factors of tumor malignant transformation and has high accuracy in distinguishing benign and malignant tumors.[23,24] CD56 is a nerve cell adhesion molecule generally expressed in natural killer cells, activated T cells, and nerve and muscle tissues, and its expression regulates the motility and migration of tumor cells. The gene discussed is LGALS3; the disease is cancer.