The p53 pathway is dysregulated in ≈85% of all GBM tumors[14] and has been implicated in invasion, migration, proliferation, evasion of apoptosis, and cancer cell stemness.[15] Despite being the most frequently gene mutated in GBM, TP53 mutations are mostly commonly observed in the PRO subtype of GBM.[5] Therefore, we introduced a R248Q hotspot mutation in the TP53 gene to recapitulate the genetic profile of the PRO GBM subtype. Here, TP53 is linked to cancer.