Pseudotemporally correlated genes specific to MES integrated dataset included differentiation markers found in astrocytes or oligo‐lineage cells, such as APOE and APOD, that also mediate pro‐inflammation and proliferation signatures in GBM.[11, 61] Genes associated with GBM tumor‐initiating cells[62] (AKT3, EPHA3, BIRC5, and EOMES) and radial glia cells (GLI3 and SOX4) were unique to the pseudotemporally correlated gene list of the PRO integrated dataset. This evidence concerns the gene APOE and neoplasm.