qRT‐PCR analysis, which was conducted after inducing ICC via the AKT/Notch intracellular domain (NICD) in primary mouse models, revealed significant downregulation of circPCSK6 in ICC compared with that in wild‐type (WT) liver tissue (Figure 1H; Figure S1D, Supporting Information). Here, AKT1 is linked to intrahepatic cholangiocarcinoma.