Additional studies established a regulatory role for EIF4A3 in ICC, as shown by the upregulation of circPCSK6‐167aa following EIF4A3 silencing, whereas EIF4A3 overexpression produced the opposite effect, indicating a potential inhibitory role of EIF4A3 in circPCSK6 formation (Figure 7B; Figure S10E, Supporting Information). The gene discussed is EIF4A3; the disease is intrahepatic cholangiocarcinoma.