Similarly, while the inhibitory effects of increased IκBα expression on ICC proliferation, anti‐apoptosis, migration, invasion, and tumor stemness could be alleviated by RBBP6 overexpression, the malignant biological behavior precipitated by the IκBα‐K22R variant remained refractory to such intervention (Figure S8A–E, Supporting Information). This evidence concerns the gene NFKBIA and intrahepatic cholangiocarcinoma.