NFKBIA and neoplasm: Ubiquitination is pivotal for protein degradation and plays a central role in various biological phenomena,[41] including tumor progression.[42] Through protein interaction studies and ubiquitination assays, we revealed that circPCSK6‐167aa thwarts the proteasomal degradation pathway of IκBα, leading to the accumulation of non‐ubiquitinated IκBα in cells.