Hypothalamic AgRP(Agouti‐related protein) neurons, which release GABA as a neurotransmitter, are key players in controlling feeding behavior,[55] and they also regulate body weight and food intake during opioid dependence and abstinence in mice.[56] However, in this study, we did not test the role of GABA‐releasing AgRP neurons during morphine addiction; further exploration will be conducted in future research. Here, AGRP is linked to opiate dependence.