These included genes involved in cancer progression (PDK4, GPX3, LMAN1, RP11-124N14.3 and PAK6), factors implicated in cytokine response (TNFRSF12A, UBE2J1 and MAP1B), as well as those important for cytoskeleton remodelling, decreased intercellular adhesion and cancer stem cell transformation (EZR and CD44). The gene discussed is CD44; the disease is cancer.