PC catalyzes the carboxylation of pyruvate to OAA, serving as a critical component in gluconeogenesis and an intermediate in the TCA cycle.[13, 17] Studies have reported that PC plays a vital role in processes such as insulin secretion, fat synthesis, and neurotransmitter biosynthesis, allowing it to be a potential target for diseases such as obesity, diabetes, viral infections, and cancer.[18, 19, 20] However, despite it being crucial for energy metabolism, PC's function in renal diseases remains unknown. Here, INS is linked to kidney disorder.