SQOR catalyzes the conversion of sulfide to persulfide in the mitochondria, thereby reducing toxic sulfide concentrations, preventing mitochondrial membrane peroxidation, maintaining mitochondrial integrity, and mitigating ferroptosis.[16, 27, 28, 29, 30] In our study, we found that PC deficiency mediated the ubiquitination and degradation of SQOR, which disrupted mitochondrial morphology and function. The gene discussed is SQOR; the disease is pachyonychia congenita.