CDH16 and renal fibrosis: To further explore the relevance and mechanism of PC in renal fibrosis, we used CRISPR‐Cas9 technology to create a model of conditionally knocked‐out PC in tubular epithelial cells of mice (Pcxflox/flox;Cdh16‐Cre, PcxcKO) (Figure3A; Figure S2A, Supporting Information).