Further single‐nucleus transcriptional data from the prefrontal cortex of individuals with varying degrees of Alzheimer's disease revealed differential expression of KDM7A across different pathological stages in six major brain cell types, including excitatory neurons, inhibitory neurons, astrocytes, oligodendrocytes, microglia, and oligodendrocyte progenitor cells.[35] Kdm7a knockdown in hippocampus leads to impairment of emotion and memory via repressing neuron activity.[31] However, the functional characterization of KDM7A in the adult brain was still largely unknown. This evidence concerns the gene KDM7A and Alzheimer disease.